The greatest challenge for evolutionary biology is to account for the information found in codes in DNA, RNA, proteins, and more recently in the epigenome. The mutation/selection mechanism of neo-Darwinism, although still taught in biology textbooks, has been shown inadequate by creation and intelligent design scientists. Indeed, even some leading evolutionists are seeking alternative mechanisms such as self-organization. Much evidence has been found against neo-Darwinism (and all related stochastic processes) and for intelligent design (ID) in recent years. Intelligent design advocates have found ways to detect design. Much evidence has been found against the macroevolution of Homo sapiens and for the biblical origin of mankind.
Evolutionists must account for the origin of life, the Cambrian Explosion in the fossil record, living fossils, the lack of transitional forms, the origin of sexuality, the origin of consciousness, the origin of information in macroevolution, the origin of irreducibly complex molecular machines, convergent evolution, and the information found in the epigenome.